Kame-hime (亀姫 Kame-hime,lit. Turtle Princess) is the master of Inawashiro Castle and the sister of Osakabe-hime.
She is the 22nd of the chosen 47 Yōkai Warriors and represents Fukushima Prefecture. Along with her sister, Osakabe-hime, Kame-hime appears and becomes one of the 47 Yōkai warriors in episode #99 of the fifth anime adaptation, City Castle Tower! Yōkai Kame-hime.
Kame-hime somehow obtained and keeps Cerberus as a pet.
In the fifth series, the sibling is noted to be "higher than yōkai" and their spiritual powers are on completely different level than normal yōkai. It is easy for them to cause large-scale disasters such as to vanish an island, to cause massive tornadoes, to transport the whole water of lake Biwako the largest lake in Japan. and to take human souls of an entire city.
Kame-hime was depicted as a big, old mujina.